Hiv Protease Inhibitors Side Effects

If this happens seek emergency medical care. May also occur with some of these agents.

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Protease inhibitors play a significant role in HAART.

Hiv protease inhibitors side effects. Symptoms of liver damage may include jaundice which is a yellowing of the skin or whites of the eyes pale-colored stool or dark-colored urine. Some side effects of protease inhibitors may be severe. What Are the Potential Side Effects When Using Protease Inhibitors.

These are synthetic drugs. Some rare severe side effects of protease inhibitors may include. Highly Active Antiretroviral Therapy HAART is one of the most effective treatments of HIV.

The most significant being a condition called HIV protease inhibitor-induced metabolic syndrome which. Common adverse events associated with protease inhibitors include gastrointestinal side effects diarrhea nausea vomiting and metabolic complications dyslipidemia insulin resistance. Protease inhibitors PIs are a class of antiviral drugs that are widely used to treat HIVAIDS and hepatitis C.

Steroidal side effects such as buffalo hump and visceral abdominal fat accumulation have been reported in association with protease inhibitors. These side effects though uncommon require emergency medical care. Although the toxic effects of HIV protease inhibitors could result from drugdrug interactions and overdose the off-target adverse drug effects of therapeutic doses is a major concern in drug design.

In the HIV life cycle protease is an essential element for viral maturation. Confirmed potential side effects of protease inhibitors are. The use of protease inhibitors as a singular treatment has ceased for many reasons including greater efficacy as part of combination treatment and side effects.

Toxicity-associated adverse events still remain a major concern when prescribing HIV protease inhibitors. Metabolic side effects include glucose intolerance diabetes hypercholesterolemia and hypertriglyceridemia. Protease inhibitors can have side effects.

Protease inhibitors prevent viral replication selectively binding to viral proteases eg. HIV-1 protease and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles. Side effects of protease inhibitors.

Although antiretroviral treatment decreases HIV-AIDS morbiditymortality long-term side effects may include the onset of insulin resistance and cardiovascular diseases. Adverse effects associated with the use of protease inhibitors nausea vomiting and diarrhea. Side effects of HIV PIs are stomach discomfort diarrhea weakness and headache.

Protease inhibitors have a significant potential for interactions with certain drugs and foods. We report two cases of severe disfiguring striae formation in patients with HIV who recently started indinavir therapy. Among those diarrhea lipid and liver enzyme elevations are predominant.

Its disadvantages are unbearable toxic and its bioavailability. 4 Irregularities in fat distribution throughout the body dyslipidemia and lipodystrophy. Side effects of hep C protease inhibitors are dizziness diarrhea fatigue headache and nausea.

The most common side effects are HIV protease inhibitor-induced metabolic syndromes such as dyslipidemia insulin-resistance and lipodystrophylipoatrophy as well as cardiovascular and cerebrovascular diseases36 Protease inhibitor monotherapy is associated with a mild improvement in body fat distribution78 However regarding the serious adverse events of antiretroviral treatments no significant between-group differences were found between HIV protease inhibitor. Most of the inhibitors are accompanied by side effects in long-term treatment. These changes occurred within 3 months of starting treatment.

HIV protease inhibitors can cause the following side effects. The most significant being a condition called HIV protease inhibitor-induced metabolic syndrome which results in. Gastrointestinal side effects such as.

Some of the major side effects of protease inhibitors include the following. Most of the inhibitors are accompanied by side effects in long-term treatment. Nausea and dizziness are potential side effects of protease inhibitors.

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